January 1, 1989Journal of Cardiovascular Pharmacology
Endothelin-1 Releases Prostacyclin and Inhibits ex vivo Platelet Aggregation in the Anesthetized Rabbit
Why the study?
Does endothelin-1 inhibit ex vivo platelet aggregation in anesthetized rabbits?
Population
Anesthetized rabbits
Comparison
Porcine endothelin vs Baseline/control and pretreatment with…
Design
Preclinical
Follow-up
30 min
Authors
Discussion
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Implication
ET-1 inhibits rabbit platelet aggregation via COX products; hypothesis-generating for human thrombosis, no practice change.
Structured PICO
Does endothelin-1 inhibit ex vivo platelet aggregation in anesthetized rabbits?
P
Population
Anesthetized rabbits
I
Intervention
Porcine endothelin (endothelin-1, ET-1; 1 nmol/kg i.a.)
C
Comparator
Baseline/control (implied) and pretreatment with indomethacin (5 mg/kg i.v., 20 min prior to ET-1)
O
Outcome
Ex vivo platelet aggregation and platelet cAMP/cGMP levelssurrogate
Endothelin-1 inhibits platelet function in vivo by stimulating the release of antiplatelet cyclo-oxygenase products such as prostacyclin.
Cite This Study
Thiemermann et al. (1989) studied this question.