Why the study?
Does human big endothelin induce prostacyclin release and inhibit platelet aggregation through conversion to endothelin-1 in animal models?
Population
Anesthetized rabbits and perfused lungs from rabbit, guinea pig, and rat
Comparison
Human big endothelin and endothelin-1 vs Phosphoramidon, indomethacin, or C-terminal…
Design
Preclinical
Authors
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Supports ET-1 mediation of big ET effects in animals; leaves open human translation and clinical relevance.
Does human big endothelin induce prostacyclin release and inhibit platelet aggregation through conversion to endothelin-1 in animal models?
Human big endothelin requires conversion to endothelin-1 by a phosphoramidon-sensitive endothelin-converting enzyme to induce prostacyclin release and inhibit platelet aggregation.
D’Orléans-Juste et al. (1991) studied this question.
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