Why the study?
Does phosphoramidon inhibit the conversion of big endothelins to active endothelins in the perfused rabbit kidney?
Population
Perfused rabbit kidney model
Comparison
Intra-arterial bolus injections of human big… vs Responses without phosphoramidon
Design
Preclinical
Authors
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No clinical implications yet; leaves open whether phosphoramidon-sensitive ECE inhibition translates to human hypertension.
Does phosphoramidon inhibit the conversion of big endothelins to active endothelins in the perfused rabbit kidney?
The study demonstrates the presence of a phosphoramidon-sensitive endothelin converting enzyme in the rabbit renal vasculature that converts big endothelin-1 and -2, but not big endothelin-3.
Télémaque et al. (1992) studied this question.
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