August 1, 1994Hypertension

Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney.

View Full Paper

Ask AI

Bookmark

Population

Isolated perfused rat kidney model

Design

Preclinical

Authors

KFKazumi FujitaKanazawa University YMY MatsumuraNational Cancer Center Hospital East SKShunbun KitaThe University of Osaka

Discussion

Member takes

Implication

Hypothesis-generating for renal ET-1 conversion in hypertension; leaves open human translation.

Structured PICO

Population

Isolated perfused rat kidney model

Intervention

Big endothelin-1 (ET-1), ET-1, phosphoramidon (10(-4) mol/L), and kelatorphan (10(-4) mol/L)

Outcome

Perfusion pressure and immunoreactive endothelin levels in perfusate and renal tissuessurrogate

A phosphoramidon-sensitive ET-1-converting enzyme contributes to the local conversion of big ET-1 to ET-1, while neutral endopeptidase 24.11 mediates ET-1 degradation in the rat kidney.

Cite This Study

Fujita et al. (1994) studied this question.

synapsesocial.com/papers/6a830bbb4e20a508b1f464f8 https://doi.org/10.1161/01.hyp.24.2.227

View Full Paper

Ask AI

Bookmark

Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider