June 29, 1992FEBS Letters

Phosphoramidon‐sensitive endothelin‐converting enzyme in vascular endothelial cells converts big endothelin‐1 and big endothelin‐3 to their mature form

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Population

Cultured vascular endothelial cells (membrane fraction and intact cells)

Comparison

Phosphoramidon vs Control (absence of phosphoramidon)

Design

Preclinical

Authors

YMYasuo MatsumuraAmerican Pharmacists Association YTYaeko TsukaharaSanten (Japan)KKKazuko KuninobuNovartis (Switzerland)

Discussion

Member takes

Implication

May support ECE as a research target for endothelin modulation; leaves open translation to human cardiovascular disease.

Structured PICO

Population

Cultured vascular endothelial cells (membrane fraction and intact cells)

Intervention

Phosphoramidon

Comparator

Control (absence of phosphoramidon)

Outcome

Conversion of big endothelin-1 and big endothelin-3 to their mature forms (ET-1 and ET-3)surrogate

Identifies a phosphoramidon-sensitive metalloproteinase (endothelin-converting enzyme) responsible for generating mature endothelin-1 and endothelin-3 in vascular endothelial cells.

Cite This Study

Matsumura et al. (1992) studied this question.

synapsesocial.com/papers/6a898a201fb56efa37d458d3 https://doi.org/10.1016/0014-5793(92)80870-m

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