Population
Cultured porcine aortic endothelial cells (ECs) and vascular smooth muscle cells (VSMCs)
Comparison
Phosphoramidon (a metalloproteinase inhibitor) vs Control (absence of phosphoramidon)
Design
Preclinical
Authors
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May modulate vascular endothelin signaling; leaves open in vivo relevance and therapeutic translation.
Phosphoramidon inhibits the metalloproteinase-dependent conversion of big endothelin-1 to mature endothelin-1 in vascular endothelial and smooth muscle cells.
Ikegawa et al. (1991) studied this question.
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