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September 15, 1992Proceedings of the National Academy of SciencesOpen Access

The endothelin-converting enzyme from human umbilical vein is a membrane-bound metalloprotease similar to that from bovine aortic endothelial cells.

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Authors

KAKyunghye AhnPfizer (United States)KBKaren A. BeningoWayne State University GOG R OldsSt. George's University

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Implication

Endothelial ECE activity identified; leaves open validation as therapeutic target in cardiovascular disease.

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Cite This Study

Ahn et al. (1992) studied this question.

synapsesocial.com/papers/6a6fe4aa35aa2c282ce134ca https://doi.org/10.1073/pnas.89.18.8606

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1Evidence for metalloprotease involvement in the in vivo effects of big endothelin 11991 · 50 citations
2Conversion of big endothelin‐1 to endothelin‐1 by two types of metalloproteinases derived from porcine aortic endothelial cells1990 · 112 citations
3Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein1992 · 55 citations
4Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo1989 · 125 citations