Population
Endothelium-denuded human umbilical vein preparation
Design
Preclinical
Authors
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May support local ET maturation in human vessels; hypothesis-generating with no current clinical implications.
The study identifies a phosphoramidon-sensitive endothelin converting enzyme in human vascular smooth muscle that converts big endothelins to their active vasoconstrictor forms.
Maguire et al. (1997) studied this question.
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