Key result
Endothelins contract the human isolated umbilical artery via ET(A) receptors, while contraction in the vein is mediated by both ET(A) and ET(B) receptors.
Population
Human isolated umbilical artery and vein
Design
Preclinical
Authors
Loading...
May guide ex vivo ET receptor studies in umbilical vessels; leaves open clinical translation.
Endothelins contract the human umbilical artery primarily via ET(A) receptors and the vein via both ET(A) and ET(B) receptors, with calcium channels playing a more prominent role in ET(B)-mediated contraction.
Bogoni et al. (1996) studied this question. Endothelins (ET-1, ET-2, ET-3) and antagonists was evaluated on Contraction of human umbilical artery and vein. Endothelins contract the human isolated umbilical artery via ET(A) receptors, while contraction in the vein is mediated by both ET(A) and ET(B) receptors.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: