What question did this study set out to answer?

To localize endothelin immunoreactivity and assess the contractile effects and receptor mechanisms of endothelin isoforms in human coronary arteries and veins.

April 1, 1994Journal of Cardiovascular Pharmacology

Localization of Endothelin Immunoreactivity and Demonstration of Constrictory Endothelin-A Receptors in Human Coronary Arteries and Veins

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To localize endothelin immunoreactivity and assess the contractile effects and receptor mechanisms of endothelin isoforms in human coronary arteries and veins.
Examined endothelin immunoreactivity in the endothelium of human epicardial coronary arteries and veins.
Assessed contractile responses to ET-1, ET-2, and ET-3 in isolated circular coronary vessel segments relative to 60 mM potassium-induced contraction.
Evaluated the effect of the selective endothelin-A receptor antagonist FR 139317 on ET-induced vasoconstriction.
ET-1, ET-2, and ET-3 produced significantly greater maximum contraction and potency in coronary veins compared to arteries, with ET-1 and ET-2 exhibiting equal maximum contraction and potency, whereas ET-3 showed lower contraction and potency in both vessel types.
FR 139317 significantly reduced the potency of ET-1 and ET-2 in both arteries and veins without significantly altering their maximum contractile response, demonstrating mediation via endothelin-A receptors.

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Implication

Ex vivo tissue analysis reveals endothelin-mediated constriction in human coronary vessels, suggesting regulation through endothelin-A receptors.

Cite This Study

Opgaard et al. (1994) studied this question.

synapsesocial.com/papers/6a8bfb45e6afc07dcbf46100 https://doi.org/10.1097/00005344-199404000-00009

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Implication

Ex vivo tissue analysis reveals endothelin-mediated constriction in human coronary vessels, suggesting regulation through endothelin-A receptors.

Localization of Endothelin Immunoreactivity and Demonstration of Constrictory Endothelin-A Receptors in Human Coronary Arteries and Veins

Key Points

Discussion

Implication

Cite This Study

Localization of Endothelin Immunoreactivity and Demonstration of Constrictory Endothelin-A Receptors in Human Coronary Arteries and Veins

Key Points

Discussion

Implication

Cite This Study

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