What question did this study set out to answer?

To investigate regional variations in endothelin-1 and its receptor subtypes across healthy and atherosclerotic human coronary vasculature.

January 1, 1998Endothelium

Regional Variations in Endothelin-1 and its Receptor Subtypes in Human Coronary Vasculature: Pathophysiological Implications in Coronary Disease

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To investigate regional variations in endothelin-1 and its receptor subtypes across healthy and atherosclerotic human coronary vasculature.
Examined human coronary artery and myocardial tissue samples from control donors and patients with ischemic heart disease.
Mapped peptide distribution and receptor subtypes across proximal, distal, and microvascular coronary regions using immunohistochemistry and in vitro autoradiography.
ET-1 immunoreactivity localized to luminal endothelial cells and smooth muscle cells within atherosclerotic regions, while ETA receptors predominated on coronary smooth muscle cells and cardiac myocytes.
Medial ETB receptor binding was weak in proximal coronary arteries but increased significantly toward distal vessels in controls (p<0.005) and ischemic heart disease tissue (p<0.0005).
Adventitial microvascular endothelial cells, myocardial microvessels, and the endocardial endothelium exclusively expressed ETB receptors.

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ET-1 receptor mapping in atherosclerotic coronaries is hypothesis-generating; prospective studies needed before clinical translation.

Dashwood et al. (1998) studied this question.

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