Key result
Human LV smooth-muscle cells secrete mature ET and big ET-1 and express mainly ETA receptors.
Why the study?
The source of endothelin in the human heart and the characterization of endothelin secretion and receptor expression in left ventricular smooth-muscle cells were not fully defined.
Smooth-muscle cells isolated from human left ventricle secrete mature endothelin and big ET-1 and express mainly ETA receptors, providing a model for studying myocardial vascular tone.
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Provides a human LV smooth-muscle cell model for ET-1 studies; leaves open relevance to in vivo myocardial vascular tone.
Peter et al. (1995) studied this question. Cell culture and receptor binding assays was evaluated on Endothelin secretion and receptor expression. Smooth-muscle cells isolated from human left ventricle secrete immunoreactive mature ET and big ET-1, and express mainly ETA receptors.
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