ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calciumThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

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Population

Isolated human aortic vascular endothelial cells (hVECs)

Design

Preclinical

Authors

Discussion

ETA receptors mediate ET-1 calcium signaling in vascular cells; hypothesis-generating with human relevance untested.

Population

Isolated human aortic vascular endothelial cells (hVECs)

Intervention

ET-1 (10-9 mol/L) with or without specific ETA receptor antagonist ABT-627 (10-7 mol/L) or ETB receptor antagonist A-192621 (10-7 mol/L)

Outcome

Total intracellular free Ca2+ levels and receptor localizationsurrogate

ETA receptors are present in human aortic vascular endothelial cells and mediate ET-1 induced increases in intracellular calcium.

Avedanian et al. (2010) studied this question.

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