Key result
In human vascular smooth muscle, the majority (at least 85%) of endothelin receptors present are the ETA sub-type, supporting ETA blockade for vasodilatation.
Authors
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May inform ET receptor antagonist selectivity in human vessels; leaves open clinical translation.
Davenport et al. (1995) studied Human vasculature (n=3). Endothelin receptor binding assays was evaluated on Ratio of ETA to ETB receptors in vascular smooth muscle media. In human vascular smooth muscle, the majority (at least 85%) of endothelin receptors present are the ETA sub-type, supporting ETA blockade for vasodilatation.
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