Endothelin ETA receptor expression in human cerebrovascular smooth muscle cells
Key result
Human cultured brain smooth muscle cells express only ETA receptor protein, despite the presence of mRNA for both ETA and ETB receptors.
Authors
Discussion
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Implication
Cell culture data should not guide clinical ET receptor targeting; leaves open the in vivo role of discrepant ETA/ETB expression.
PICO
P
Population
In vitro cultures of vascular smooth muscle cells explanted from human cerebral resistance vessels from 3 individuals.
E
Exposure / Comparator
Endothelin receptor characterization
O
Primary Outcome
Endothelin receptor expression
Cite This Study
Yu et al. (1995) studied Cerebrovasospasm (n=3). Endothelin receptor characterization was evaluated on Endothelin receptor expression. Human cultured brain smooth muscle cells express only ETA receptor protein, despite the presence of mRNA for both ETA and ETB receptors.