Population
Human cerebral arteries with and without endothelium
Comparison
Endothelin-1 and sarafotoxin 6c in the presence… vs Absence of endothelin blockers
Design
Preclinical
Authors
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Supports distinct ETA/ETB roles in cerebral vasoregulation; leaves open translation to human cerebrovascular therapeutics.
In human cerebral arteries, ET-1-induced vasoconstriction is primarily mediated by the ETA receptor, whereas sarafotoxin 6c-induced vasodilatation is mediated via the ETB receptor.
Nilsson et al. (1997) studied this question.
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