Population
Goat isolated middle cerebral arteries
Design
Preclinical
Authors
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No immediate clinical implications for cerebrovascular tone; leaves open ETA receptor subtype heterogeneity for further study.
ETA receptors mediate vasoconstriction to endothelin-1 and sarafotoxin S6b in the goat middle cerebral artery, with different antagonistic potencies suggesting the existence of ETA receptor subtypes.
Salom et al. (1993) studied this question.
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