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March 1, 1992British Journal of PharmacologyOpen Access

Heterogeneity of endothelin‐sarafotoxin receptors mediating contraction of pig coronary artery

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Population

Endothelium-denuded rings of pig coronary artery

Design

Preclinical

Authors

VHVanessa J. HarrisonWilliam Harvey Research Institute ARAdolphe RandriantsoaCentre National de la Recherche Scientifique PSPhilippe SchoeffterNovartis (Switzerland)

Discussion

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Implication

Indicates multiple endothelin receptor subtypes in porcine coronaries; leaves open human relevance and therapeutic targeting.

Structured PICO

P

Population

Endothelium-denuded rings of pig coronary artery

I

Intervention

Endothelin-1, endothelin-3, sarafotoxin 6b and sarafotoxin 6c

O

Outcome

Contractile effects (concentration-response curves and EC50 values)surrogate

The study suggests the presence of at least two distinct endothelin-sarafotoxin receptors mediating contraction in pig coronary arteries.

Cite This Study

Harrison et al. (1992) studied this question.

synapsesocial.com/papers/6a830aa45b5082326951ad11 https://doi.org/10.1111/j.1476-5381.1992.tb09009.x

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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.1989 · 2,532 citations
2A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.1980 · 1,625 citations
3Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.1991 · 358 citations