Comparative responses to endothelin-2 and sarafotoxin 6b in the pulmonary vascular bed of the cat

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Population

Feline pulmonary vascular bed (cats) under natural flow and constant flow conditions

Comparison

Injections of endothelin-2 and sarafotoxin 6b vs U46619 and an ET analog with only the Cys1-Cys15…

Design

Preclinical

Authors

Discussion

Highlights potential endothelin targets in pulmonary vascular disease; extends preclinical data but leaves open human translation.

Population

Feline pulmonary vascular bed (cats) under natural flow and constant flow conditions

Intervention

Injections of endothelin-2 and sarafotoxin 6b (0.3 nmol/kg iv, and 0.1-1 nmol into perfused lobar artery)

Comparator

U46619 (thromboxane A2 mimic) and an ET analog with only the Cys1-Cys15 disulfide bond

Outcome

Changes in pulmonary arterial pressure, left atrial pressure, cardiac output, pulmonary vascular resistance, and systemic arterial pressuresurrogate

Endothelin-2 and sarafotoxin 6b exhibit significant vasoconstrictor activity in the feline pulmonary vascular bed.

Minkes et al. (1991) studied this question.

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