Why the study?
What are the regional hemodynamic effects of endothelin-2 and sarafotoxin-S6b in conscious rats?
Population
Conscious Long-Evans and Brattleboro rats chronically instrumented with pulsed Doppler flow probes
Comparison
Bolus doses and 60-min infusions of endothelin-2… vs Comparison between ET-2 and S6b, and between…
Design
Preclinical
Follow-up
60 minutes (infusion duration)
Authors
Loading...
Rat hemodynamics show S6b exceeds ET-2 in dual vascular potency; leaves open translation to human endothelin biology.
What are the regional hemodynamic effects of endothelin-2 and sarafotoxin-S6b in conscious rats?
Sarafotoxin-S6b demonstrates more potent in vivo vasodilator and vasoconstrictor effects compared to endothelin-2 in conscious rats.
Gardiner et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: