Population
Conscious dogs instrumented with ultrasonic flow probes for measurement of blood flow in the ascending aorta…
Comparison
Constant infusions of endothelin-1 at 5, 10, or… vs Sarafotoxin S6b infused in identical experiments…
Design
Preclinical
Follow-up
1 h
Authors
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These dog data warrant no clinical translation; leaves open endothelin receptor subtype heterogeneity for targeted research.
The regional variability in hemodynamic responses to ET-1 and S6b in conscious dogs suggests the existence of heterogeneous receptor subtypes for these peptides.
Leadley et al. (1991) studied this question.
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