Population
Conscious Long Evans and Brattleboro rats, chronically-instrumented with pulsed Doppler flow probes
Comparison
Endothelin-1 and endothelin-3 administered as… vs Comparison between endothelin-1 and…
Design
Preclinical
Authors
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ET-1's stronger delayed vasoconstriction versus ET-3 in rats; leaves open isoform-specific endothelin targeting in human hypertension.
Endothelin-1 and endothelin-3 exhibit similar initial vasodilator effects, but endothelin-1 produces a greater delayed pressor and vasoconstrictor response, independent of endogenous vasopressin.
Gardiner et al. (1990) studied this question.
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