Key result
Intra-arterial infusion of endothelin-1 in humans caused dose-dependent decreases in forearm blood flow of 25-42%, and at a higher dose elicited severe adverse reactions including pain and edema.
Why the study?
What are the regional haemodynamic effects and adverse reactions of endothelin-1 infusion in humans and rats?
What are the regional haemodynamic effects and adverse reactions of endothelin-1 infusion in humans and rats?
Endothelin-1 infusion causes significant regional vasoconstriction and at high doses induces severe adverse effects including pain and edema due to increased capillary hydrostatic pressure.
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Endothelin-1 infusion warrants caution for vasoconstriction and adverse effects; leaves open its role in human hypertension research.
Dahlöf et al. (1990) studied this question. Endothelin-1 was evaluated on Forearm blood flow. Intra-arterial infusion of endothelin-1 in humans caused dose-dependent decreases in forearm blood flow of 25-42%, and at a higher dose elicited severe adverse reactions including pain and edema.
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