Why the study?
Does intravenous endothelin-1 infusion alter regional hemodynamics and endothelin-1 clearance in healthy men?
Population
6 healthy men
Comparison
Constant intravenous infusion of endothelin-1 vs Control (placebo) period
Design
Other
Authors
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Endothelin-1 effects in healthy men should not change practice; leaves open its role in renal disease and therapeutic targeting.
Does intravenous endothelin-1 infusion alter regional hemodynamics and endothelin-1 clearance in healthy men?
In healthy men, exogenous endothelin-1 infusion causes significant renal vasoconstriction and demonstrates that renal and limb uptake contribute to its clearance.
Gasić et al. (1992) studied this question.
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