Key result
IV Big endothelin-1 increases systemic vascular resistance ~65%, raising blood pressure and lowering cardiac output.
Why the study?
Does intravenous Big endothelin-1 infusion alter central and regional hemodynamics in healthy men?
Population
6 healthy men
Comparison
Intravenous infusion of Big endothelin-1 vs Baseline and historical equimolar ET-1 infusion
Design
Other
Authors
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Big ET-1 infusion alters hemodynamics in healthy men; leaves open its role in hypertension or heart failure.
Does intravenous Big endothelin-1 infusion alter central and regional hemodynamics in healthy men?
p-value: p=<0.001
Circulating Big ET-1 elicits significant increases in mean arterial blood pressure and systemic vascular resistance, and decreases in heart rate and cardiac output in healthy humans.
Ahlborg et al. (1996) studied Healthy (n=6). Big endothelin-1 (Big ET-1) vs. Equimolar ET-1 infusion was evaluated on Hemodynamic effects including heart rate, cardiac output, and blood pressure (p=<0.001). Intravenous infusion of Big endothelin-1 increased mean arterial blood pressure by 18% and systemic vascular resistance by 65%, while decreasing heart rate by 17% and cardiac output by 26% (P<0.001).
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