What question did this study set out to answer?

To evaluate the regional vascular effects and organ-specific plasma elimination of endothelin-1 across the human pulmonary, cerebral, and skeletal muscle circulations.

November 1, 1993Clinical Physiology

Differences in vascular effects and removal of endothelin‐1 in human lung, brain, and skeletal muscle,

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Why the study?

What are the regional differences in vascular effects and removal of endothelin-1 in healthy volunteers?

Population

10 healthy volunteers

Design

Other

Follow-up

up to 1 hour post-infusion

Authors

EWEddie WeitzbergKarolinska University Hospital GAG. AhlborgSödertörn University JLJan M. LundbergAstraZeneca (United Kingdom)

Discussion

Member takes

Implication

Lung ET-1 extraction appears prominent in healthy humans; leaves open its net vascular effects in disease states.

Key Points

To evaluate the regional vascular effects and organ-specific plasma elimination of endothelin-1 across the human pulmonary, cerebral, and skeletal muscle circulations.
Administered intravenous endothelin-1 infusion (4 pmol kg⁻¹ min⁻¹ for 20 minutes) to 10 healthy volunteers.
Measured plasma endothelin-1-like immunoreactivity, organ-specific fractional extraction across vascular beds, and systemic hemodynamic parameters.
Fractional extraction of endothelin-1 was 41% across pulmonary and 30% across skeletal muscle beds, whereas no fractional extraction occurred across the cerebral circulation.
Endothelin-1 infusion reduced heart rate by 10%, cardiac output by 14%, and stroke volume by 8%, while increasing mean arterial blood pressure by 7% (all P < 0.05).
Pulmonary and systemic vascular resistance increased by 67% and 25%, respectively (P < 0.05), whereas arterio-venous oxygen differences decreased across cerebral and skeletal muscle vascular beds (P < 0.05).

Structured PICO

What are the regional differences in vascular effects and removal of endothelin-1 in healthy volunteers?

Population

10 healthy volunteers

Intervention

Intravenous infusion of endothelin-1 (ET-1) at 4 pmol kg-1 min-1 for 20 min

Outcome

Fractional extraction of ET-1-LI across pulmonary, skeletal muscle, and cerebral vascular beds, and hemodynamic/vascular effectssurrogate

Endothelin-1 exhibits regional differences in clearance, primarily by the lungs, and exerts both vasoconstrictive and vasodilatory actions in humans.

Cite This Study

Weitzberg et al. (1993) studied this question.

synapsesocial.com/papers/6a830abba353bb944193c83c https://doi.org/10.1111/j.1475-097x.1993.tb00480.x

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Differences in vascular effects and removal of endothelin‐1 in human lung, brain, and skeletal muscle,

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Differences in vascular effects and removal of endothelin‐1 in human lung, brain, and skeletal muscle,

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider