Key result
IV endothelin-1 cuts splanchnic blood flow ~18% vs control, lowering renal flow and glucose production.
Why the study?
Does intravenous endothelin-1 alter splanchnic and renal blood flow and glucose production in healthy subjects?
Population
12 healthy subjects
Comparison
Endothelin-1 0.2 pmol.kg-1.min-1 intravenously… vs Physiological saline intravenously
Design
Other
Follow-up
60 minutes
Authors
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Minimal ET-1 elevations may impair regional perfusion and glucose output in health; hypothesis-generating for its role in disease states with higher levels.
Does intravenous endothelin-1 alter splanchnic and renal blood flow and glucose production in healthy subjects?
Minimal increases in circulating endothelin-1 significantly reduce splanchnic and renal blood flow and splanchnic glucose production in healthy humans.
Ahlborg et al. (1995) studied Healthy (n=12). Endothelin-1 (ET-1) vs. Physiological saline was evaluated on Splanchnic blood flow, renal blood flow, and splanchnic glucose production. Intravenous infusion of endothelin-1 in healthy subjects reduced splanchnic blood flow by 18%, renal blood flow by 10%, and splanchnic glucose production by 42% compared with control.
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