Key result
Intravenous infusion of ET-1 and big ET-1 induced comparable increases in blood pressure and coronary constriction, reducing coronary sinus blood flow by a maximum of 25% and 28%, respectively.
Why the study?
What are the effects of intravenous Endothelin-1 and big Endothelin-1 on coronary blood flow and blood pressure in healthy subjects?
Population
Healthy subjects
Design
Other
Follow-up
Acute (during 10-20 minute infusions)
Authors
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ET-1 and big ET-1 comparably constrict coronary vessels in healthy humans; leaves open their pathogenic role and therapeutic targeting in coronary disease.
What are the effects of intravenous Endothelin-1 and big Endothelin-1 on coronary blood flow and blood pressure in healthy subjects?
ET-1 and big ET-1 induce comparable, potent coronary constriction and blood pressure elevation in humans in vivo.
Pernow et al. (1996) studied Healthy. Endothelin-1 (ET-1) and big Endothelin-1 vs. Baseline was evaluated on Mean arterial blood pressure and coronary sinus blood flow. Intravenous infusion of ET-1 and big ET-1 induced comparable increases in blood pressure and coronary constriction, reducing coronary sinus blood flow by a maximum of 25% and 28%, respectively.
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