Why the study?
Does endothelin-1 affect basal vascular tone and autoregulatory vasodilation in the coronary microcirculation of anesthetized dogs?
Population
Anesthetized open-chest dogs (n=22 total; 6 in dose-response group, 16 in pressure reduction group)
Comparison
Endothelin-1 superfused onto the epimyocardium… vs Absence of ET-1 and baseline conditions
Design
Preclinical
Authors
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Hypothesis-generating in canine coronary microcirculation; leaves open translation to human autoregulation or ET-1 therapies.
Does endothelin-1 affect basal vascular tone and autoregulatory vasodilation in the coronary microcirculation of anesthetized dogs?
Low doses of endothelin-1 increase basal coronary vascular tone but do not impair autoregulatory vasodilation during reduced perfusion pressure in a canine model.
Wang et al. (1999) studied this question.
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