Effects of endothelin on the coronary vascular bed in open-chest dogs.
Population
Open-chest anesthetized dogs with the circumflex coronary artery cannulated and perfused at a constant…
Design
Preclinical
Authors
Discussion
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Implication
Endothelin vasoconstriction in animal models is hypothesis-generating for vasospasm; leaves open human relevance pending clinical studies.
Structured PICO
P
Population
Open-chest anesthetized dogs with the circumflex coronary artery cannulated and perfused at a constant pressure of 100 mm Hg
I
Intervention
Endothelin injected intracoronarily (doses of 1, 3, and 10 micrograms)
O
Outcome
Circumflex blood flow, transmural distribution of coronary blood flow, circumflex coronary artery diameter, and circumflex luminal surface areasurrogate
Endothelin acts as a potent coronary vasoconstrictor with selective subepicardial effects, highlighting its potential role in coronary vasospasm.
Cite This Study
Clozel et al. (1989) studied this question.