Key result
Endothelial removal in anesthetized dogs selectively potentiated the constrictor response to 5-hydroxytryptamine, causing a 10-fold increase in sensitivity.
Why the study?
Does endothelial removal potentiate vasoconstrictor responses to 5-hydroxytryptamine in the intact coronary circulation of dogs?
Population
Anesthetized adult mongrel dogs (n=17)
Comparison
Endothelial removal via mechanical disruption… vs Intact endothelium (baseline state before removal)
Design
Preclinical
Authors
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Endothelial integrity may attenuate large coronary vasoconstriction in vivo; leaves open its role in human vasospasm.
Does endothelial removal potentiate vasoconstrictor responses to 5-hydroxytryptamine in the intact coronary circulation of dogs?
Effect estimate: 10-fold increase in sensitivity
Absolute Event Rate: 132% vs 54%
Endothelial removal selectively potentiates the constrictor responses to 5-hydroxytryptamine in the intact canine coronary circulation, demonstrating the endothelium's role in modulating in vivo coronary vasoregulation.
Lamping et al. (1985) studied Normal coronary circulation (animal model) (n=17). Endothelial removal vs. Endothelium intact was evaluated on Decrease in coronary diameter in response to 50 micrograms/min of 5-hydroxytryptamine (microns) (10-fold increase in sensitivity). Endothelial removal in anesthetized dogs selectively potentiated the constrictor response to 5-hydroxytryptamine, causing a 10-fold increase in sensitivity.
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