Key result
In canine coronary microvessels, acetylcholine caused dose-dependent vasodilation (maximum relaxation 97.9 +/- 2.1%), while responses to vasopressin and thrombin differed from large arteries.
Why the study?
Does the endothelium modulate vascular reactivity to acetylcholine, vasopressin, and thrombin differently in canine coronary microvessels compared to large epicardial arteries?
Population
Canine coronary resistance vessels and large epicardial vessels studied in vitro
Comparison
Exposure to acetylcholine, vasopressin, and… vs Comparison between microvessels and large…
Design
Preclinical
Authors
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Caution against extrapolating in vitro canine microvessel data to patients; leaves open human in vivo confirmation.
Does the endothelium modulate vascular reactivity to acetylcholine, vasopressin, and thrombin differently in canine coronary microvessels compared to large epicardial arteries?
The endothelium of coronary microvessels modulates vascular reactivity similarly to large vessels for acetylcholine, but major differences exist in their responses to vasopressin and thrombin.
Myers et al. (1989) studied Canine coronary resistance arteries. Acetylcholine, vasopressin, and thrombin vs. Large epicardial vessels was evaluated on Vascular reactivity (vasodilation or constriction). In canine coronary microvessels, acetylcholine caused dose-dependent vasodilation (maximum relaxation 97.9 +/- 2.1%), while responses to vasopressin and thrombin differed from large arteries.
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