July 1, 1987CirculationOpen Access

Preferential increase in subendocardial perfusion produced by endothelium-dependent vasodilators.

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Population

Anesthetized dogs

Comparison

Intracoronary infusion of endothelium-dependent… vs Control (baseline before infusion)

Design

Preclinical

Authors

LPLorie R. PelcStanford University GGG J GrossMedical College of Wisconsin DWDavid C. WarltierGeneral Cardiology

Discussion

Member takes

Implication

This pathway may offer a novel target for subendocardial ischemia; leaves open clinical relevance pending human validation.

Structured PICO

Population

Anesthetized dogs

Intervention

Intracoronary infusion of endothelium-dependent vasodilators (acetylcholine 10 micrograms/min, ATP 20 micrograms/min, arachidonic acid 600 micrograms/min) and endothelium-independent vasodilator (nifedipine 5 micrograms/min), before and after a 30 min intracoronary infusion of quinacrine (300 micrograms/min)

Comparator

Control (baseline before infusion)

Outcome

Transmural myocardial blood flow and ratio of subendocardial to subepicardial blood flow (endo/epi)surrogate

Endothelium-dependent vasodilators preferentially increase subendocardial perfusion via a product of unsaturated fatty acid metabolism.

Cite This Study

Pelc et al. (1987) studied this question.

synapsesocial.com/papers/6a8c2f3f95f0361a9ebf08d2 https://doi.org/10.1161/01.cir.76.1.191

View Full Paper

Ask AI

Bookmark

Preferential increase in subendocardial perfusion produced by endothelium-dependent vasodilators.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Preferential increase in subendocardial perfusion produced by endothelium-dependent vasodilators.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider