Variable effect of nifedipine on myocardial blood flow at three grades of coronary occlusion in the dog.
Why the study?
Does intracoronary nifedipine alter regional myocardial blood flow at various grades of coronary occlusion in a canine model?
Population
22 open-chest dogs undergoing carotid to left anterior descending perfusion with flow and perfusion pressure…
Comparison
Intracoronary injection of 10 microgram of… vs Baseline (before intracoronary injection)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May cause endocardial steal in severe occlusion; animal data leave clinical relevance open.
Structured PICO
Does intracoronary nifedipine alter regional myocardial blood flow at various grades of coronary occlusion in a canine model?
P
Population
22 open-chest dogs undergoing carotid to left anterior descending perfusion with flow and perfusion pressure monitoring, divided into three groups based on grade of coronary occlusion (moderate, severe, more severe).
I
Intervention
Intracoronary injection of 10 microgram of nifedipine
C
Comparator
Baseline (before intracoronary injection)
O
Outcome
Regional myocardial blood flow measured with radioactive microspheressurrogate
The effect of nifedipine on myocardial blood flow depends on the severity of coronary occlusion, potentially causing detrimental redistribution of blood flow from endocardium to epicardium in severe stenosis.
Cite This Study
Weintraub et al. (1981) studied this question.