January 1, 1982CirculationOpen Access

The effects of nifedipine on myocardial blood flow and contraction during ischemia in the dog.

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Why the study?

Does nifedipine improve myocardial blood flow and contraction during ischemia in a dog model?

Population

23 open-chest dogs undergoing carotid-to-left anterior coronary artery perfusion with partial coronary…

Design

Preclinical

Authors

WWWilliam WeintraubBoston University SHSeiko HattoriKeio University JAJai B. AgarwalThe Metropolitan Opera (United States)

Discussion

Member takes

Implication

Nifedipine may enhance ischemic segment function independent of local flow in dogs; leaves open translation to human ischemia management.

Structured PICO

Does nifedipine improve myocardial blood flow and contraction during ischemia in a dog model?

Population

23 open-chest dogs undergoing carotid-to-left anterior coronary artery perfusion with partial coronary occlusion to 25 mm Hg diastolic perfusion pressure

Intervention

Intracoronary nifedipine (10 micrograms, n=10) or intravenous nifedipine (3 micrograms/kg/min, n=13)

Outcome

Myocardial blood flow and segmental shortening (contraction) in ischemic and nonischemic zonessurrogate

Nifedipine appears to have a direct beneficial effect on ischemic myocardium contraction independent of changes in ischemic zone blood flow in a canine model.

Cite This Study

Weintraub et al. (1982) studied this question.

synapsesocial.com/papers/6a711b9c84cc45bb7bdfe186 https://doi.org/10.1161/01.cir.65.1.49

View Full Paper

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The effects of nifedipine on myocardial blood flow and contraction during ischemia in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effects of nifedipine on myocardial blood flow and contraction during ischemia in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider