Key result
Pharmacologic vasodilation produces greater total coronary blood flow than reactive hyperemia, preferentially perfusing the subepicardium.
Why the study?
Does pharmacologic vasodilation produce different coronary blood flow responses compared to ischemia-induced vasodilation in dogs?
Population
Open-chest anesthetized dogs
Comparison
Drug-induced coronary artery vasodilation vs Ischemia-induced coronary artery vasodilation
Design
Preclinical
Authors
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Highlights underestimation of vasodilator reserve by reactive hyperemia in canines; hypothesis-generating for human transmural perfusion and requires clinical validation.
Does pharmacologic vasodilation produce different coronary blood flow responses compared to ischemia-induced vasodilation in dogs?
Total coronary vasodilator reserve is greater than that observed at the peak of reactive hyperemia, with a transmural gradient showing greater reserve in subepicardial layers.
Warltier et al. (1981) studied this question. Pharmacologic coronary artery vasodilation vs. Ischemia-induced coronary artery vasodilation (90-s occlusion) was evaluated on Total coronary and regional myocardial blood flow. Pharmacologic coronary artery vasodilation produced greater total coronary blood flow than reactive hyperemia and preferentially distributed flow to the subepicardium.
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