What question did this study set out to answer?

The aim is to investigate how intracoronary adenosine affects reactive hyperemia after brief coronary occlusions in the myocardium.

June 1, 1985AJP Heart and Circulatory Physiology

Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion

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Why the study?

Does intracoronary adenosine enhance myocardial reactive hyperemia after brief coronary occlusion in an open-chest dog model?

Population

Open-chest dog model

Comparison

Intracoronary adenosine infusion vs Control, aminophylline pretreatment, left atrial…

Design

Preclinical

Authors

DSDaiji SaitoCity Hospital THTatsuo HyodoOkayama University KTK TakedaNagoya City University

Discussion

Member takes

Implication

Warrants no change in clinical practice; leaves open adenosine's mechanistic role in human coronary reactive hyperemia.

Key Points

The aim is to investigate how intracoronary adenosine affects reactive hyperemia after brief coronary occlusions in the myocardium.
Open-chest dog model used to assess effects of adenosine infusion
Threshold dose of adenosine administered intracoronarily
Aminophylline pretreatment evaluated for its effect on hyperemia
Adenosine enhanced total hyperemic flow following all occlusions (5, 10, 15, 20, and 30 s)
Aminophylline pretreatment reduced hyperemia below control levels despite adenosine infusion
Adenosine and papaverine had no effect on hyperemic response to shorter occlusions (5 and 15 s)

Structured PICO

Does intracoronary adenosine enhance myocardial reactive hyperemia after brief coronary occlusion in an open-chest dog model?

Population

Open-chest dog model

Intervention

Intracoronary adenosine infusion (threshold dose not increasing nonocclusive flow by >10%)

Comparator

Control (baseline/no infusion), aminophylline pretreatment, left atrial adenosine injection, and intracoronary papaverine

Outcome

Total hyperemic flow (myocardial reactive hyperemia) following brief coronary occlusions (5, 10, 15, 20, and 30 s)surrogate

Exogenous intracoronary adenosine enhances myocardial reactive hyperemia after brief ischemia, suggesting it potentiates the effects of endogenous adenosine.

Cite This Study

Saito et al. (1985) studied this question.

synapsesocial.com/papers/6a6fc6fcb27f15817827165a https://doi.org/10.1152/ajpheart.1985.248.6.h812

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Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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