Why the study?
Does intracoronary aminophylline affect coronary reactive hyperaemia following brief and long occlusion periods in anaesthetised dogs?
Population
Anaesthetised, open-chest dogs
Comparison
Intracoronary aminophylline infusion vs Baseline/control responses without aminophylline
Design
Preclinical
Authors
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Aminophylline partially attenuates longer reactive hyperaemia in dogs; leaves open adenosine's role in human coronary flow regulation.
Does intracoronary aminophylline affect coronary reactive hyperaemia following brief and long occlusion periods in anaesthetised dogs?
Aminophylline partially attenuates reactive hyperaemia after longer coronary occlusions, suggesting adenosine is partially involved in mediating this physiological response.
Schütz et al. (1977) studied this question.
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