Why the study?
Does aminophylline alter coronary functional hyperemia and myocardial adenosine levels elicited by norepinephrine in dogs?
Population
31 dogs
Comparison
Aminophylline 100 mg injection during… vs Norepinephrine infusion before aminophylline…
Design
Preclinical
Authors
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Does not support adenosine in canine norepinephrine-induced coronary hyperemia; leaves open alternative mechanisms for investigation.
Does aminophylline alter coronary functional hyperemia and myocardial adenosine levels elicited by norepinephrine in dogs?
These results do not support a role for adenosine in functional hyperemia elicited by norepinephrine in the canine heart.
Jones et al. (1982) studied this question.
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