Why the study?
Does intravenous aminophylline improve coronary blood-oxygen exchange in anesthetized dogs?
Does intravenous aminophylline improve coronary blood-oxygen exchange in anesthetized dogs?
Intravenous aminophylline fails to improve myocardial oxygenation in normal or infarcted canine hearts, in contrast to nitroglycerin.
Aminophylline shows no myocardial oxygenation benefit in canine hearts; hypothesis-generating for human studies and should not yet change practice.
The effects of intravenous injections of aminophylline on the coronary blood flow, cardiac oxygen consumption, cardiac work, and cardiac rate were studied by catheterization of the right ventricle and coronary sinus in anesthetized dogs. There was no substantial increase in coronary flow when cardiac activity increased following injection of the drug; this suggested that the oxygenation of the myocardium in general was not improved. Further studies on coronary blood-oxygen saturations substantiated this concept as pertaining to the infarcted heart of dogs as well as the normal. Nitroglycerin however increased general myocardial oxygenation in normal hearts.
No takes yet. Share an insight, caveat, or question.
Foltz et al. (1950) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: