Population
Acutely transplanted dog heart model
Design
Preclinical
Authors
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May warrant caution with low-dose aminophylline; leaves open translation to human coronary physiology.
Aminophylline exhibits dose-dependent effects on coronary blood flow in the isolated dog heart, with low doses causing vasoconstriction likely via adenosine inhibition, and high doses causing direct vasodilation and positive inotropy.
Paoloni et al. (1975) studied this question.
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