Why the study?
Does aminophylline alter coronary reactive and functional hyperaemic responses in conscious dogs?
Population
Chronic, heart-blocked dog preparation
Comparison
Intravenous bolus administration of aminophylline vs Control period (baseline)
Design
Preclinical
Authors
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Adenosine may mediate prolonged but not beat-to-beat coronary hyperemia in dogs; hypothesis-generating for human coronary regulation.
Does aminophylline alter coronary reactive and functional hyperaemic responses in conscious dogs?
Adenosine appears to play a role in the coronary vascular response to prolonged interventions, but not in the beat-to-beat regulation of coronary vascular resistance.
Radford et al. (1984) studied this question.
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