Population
Canine calf muscles
Comparison
Aminophylline (10 mg/kg) infusion vs Before aminophylline infusion (baseline)
Design
Preclinical
Authors
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Questions adenosine's role in canine exercise hyperemia; leaves open relevance to human skeletal muscle blood flow.
Aminophylline does not affect sustained exercise hyperemia in canine calf muscles, suggesting interstitial fluid adenosine concentration does not increase under these conditions.
Thompson et al. (1986) studied this question.
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