Population
Isolated canine anterior calf muscles
Comparison
Muscle contraction (2- or 6-Hz) vs Precontraction level
Design
Preclinical
Authors
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Questions adenosine mediation of skeletal muscle hyperemia in this model; leaves open alternative mechanisms for human studies.
The study demonstrates that adenosine released into the interstitial space is not the cause of free-flow exercise hyperemia in skeletal muscle.
Phair et al. (1979) studied this question.
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