Population
22 pairs of adult mongrel dogs undergoing cross-circulation perfusion of isolated hindlimb muscles
Comparison
Perfusion at constant pressure or constant flow… vs Resting state (intact flow)
Design
Preclinical
Authors
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Animal data support adenosine/AMP mediation of skeletal muscle hyperemia; leaves open translation to human cardiovascular physiology.
Adenosine and/or AMP act as physiological mediators of exercise and reactive hyperemia in canine skeletal muscle, supported by potassium ions and local hypoxia.
Tominaga et al. (1975) studied this question.
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