Population
Isolated, blood-perfused dog calf muscles
Comparison
6 Hz stimulation for 10 min at free flow vs Rest (before exercise) and isoproterenol infusion
Design
Preclinical
Authors
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Supports adenosine release during exercise in animal models; leaves open translation to human cardiovascular physiology.
The study demonstrates that interstitial adenosine concentration increases during sustained free flow twitch exercise, leading to increased release into venous plasma.
Fuchs et al. (1986) studied this question.
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