Key result
Prolonged intracoronary adenosine produces ~2-fold greater late coronary vasodilation than post-ischemic reactive hyperemia.
Why the study?
Does prolonged intracoronary adenosine infusion increase coronary blood flow beyond post-ischaemic reactive peak flow in anaesthetised dogs?
Population
11 anaesthetised, open-chest dogs
Comparison
Continuous intracoronary adenosine infusion at a… vs 30 s period of ischaemia
Design
Preclinical
Follow-up
up to 2 hours
Authors
Loading...
Questions maximal flow assumptions in canine models; human translation studies required before any clinical consideration.
Does prolonged intracoronary adenosine infusion increase coronary blood flow beyond post-ischaemic reactive peak flow in anaesthetised dogs?
Prolonged intracoronary adenosine infusion induces a late, time-dependent vasodilation that doubles peak reactive hyperaemic flow, challenging the concept that post-ischaemic flow is the absolute maximum.
LʼAbbate et al. (1981) studied this question. Intracoronary adenosine infusion vs. 30 s period of ischaemia (reactive peak hyperaemia) was evaluated on Coronary vasodilating response. Prolonged intracoronary adenosine infusion produced a late coronary vasodilation response that was on average twice as great as that observed during post-ischaemic reactive hyperaemia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: