Key result
Topical endothelin constricted all coronary arteries and arterioles, whereas intracoronary administration dilated small arterioles and had no effect on large arterioles.
Population
Anesthetized dogs (n = 39)
Design
Preclinical
Authors
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Route-specific endothelin effects on coronary microvessels are hypothesis-generating in animals; human translation and clinical relevance remain unproven.
The coronary microvascular response to endothelin is highly dependent on the route of administration, suggesting a diffusional barrier or differential release of endothelium-derived factors.
Lamping et al. (1992) studied this question. Endothelin-1 was evaluated on Coronary microvascular response. Topical endothelin constricted all coronary arteries and arterioles, whereas intracoronary administration dilated small arterioles and had no effect on large arterioles.
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