Key result
Endothelin-1 infusion in conscious dogs produced a biphasic heart rate response, increasing at 2.5 ng/kg.min (129 to 146 beats/min) and decreasing at 20 ng/kg.min (97 beats/min) (p<0.001).
Why the study?
Does endothelin-1 infusion alter cardiovascular hemodynamics and endocrine markers in conscious dogs?
Population
15 conscious dogs (9 in the intervention group, 6 in the time-control group)
Comparison
Endothelin-1 infused at increasing doses vs Time-control group of six dogs
Design
Preclinical
Follow-up
4 hours (1 hour per dose)
Authors
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Should not alter clinical practice; leaves open translation of endothelin-1 effects from dogs to humans.
Does endothelin-1 infusion alter cardiovascular hemodynamics and endocrine markers in conscious dogs?
Endothelin-1 produces dose-dependent, biphasic hemodynamic effects and stimulates atrial natriuretic factor release in conscious dogs.
Donckier et al. (1991) studied this question. Endothelin-1 vs. Time-control group was evaluated on Cardiovascular and endocrine effects. Endothelin-1 infusion in conscious dogs produced a biphasic heart rate response, increasing at 2.5 ng/kg.min (129 to 146 beats/min) and decreasing at 20 ng/kg.min (97 beats/min) (p<0.001).
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