Key result
Long-term infusion of endothelin-1 increased mean arterial pressure by 16-19% and decreased renal blood flow and GFR similarly in control dogs and those with renin-angiotensin system blockade.
Why the study?
Does the renin-angiotensin system mediate the long-term cardiovascular and renal actions of endothelin in conscious dogs?
Population
Conscious dogs
Comparison
Infusion of endothelin-1 for 8 days at a rate of… vs Control dogs vs. dogs pretreated with CEI vs…
Design
Preclinical
Follow-up
8 days
Authors
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ET-1 raises BP and impairs renal function independently of RAS in dogs; leaves open human relevance and therapeutic targeting.
Does the renin-angiotensin system mediate the long-term cardiovascular and renal actions of endothelin in conscious dogs?
Long-term increases in circulating endothelin produce significant increases in arterial pressure and decreases in renal function that are not mediated by the renin-angiotensin system.
Wilkins et al. (1995) studied this question. Endothelin-1 vs. Control dogs (no pretreatment) was evaluated on Mean arterial pressure (MAP). Long-term infusion of endothelin-1 increased mean arterial pressure by 16-19% and decreased renal blood flow and GFR similarly in control dogs and those with renin-angiotensin system blockade.
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